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The MASCC/ESMO guidelines recommend that patients receiving HEC are given a dose of 20 mg dexamethasone on Day 1 to prevent acute emesis; however, if the NK 1 RAs aprepitant or netupitant are also used, a reduced dose of 12 mg dexamethasone is recommended. The annual incidence of carboplatin-related hypersensitivity reactions in 735 women with ovarian, fallopian tube, or primary peritoneal cancers. NCT00567190, NCT02402712, NCT01358877, NCT00545688, NCT00976989, NCT02132949, NCT03493854, NCT03674112. doi: 10.1007/s10147-014-0731-1. Haanen JBAG, Carbonnel F, Robert C, Kerr KM, Peters S, Larkin J, Jordan K; ESMO Guidelines Committee. In Taiwan, carboplatin was first introduced for the treatment of ovarian cancer in 2004. (PDF) Management of toxicities from immunotherapy: ESMO - ResearchGate Carboplatin hypersensitivity. Discontinuations due to anaphylaxis/hypersensitivity were rare for PH IV (generally <1% except two TRYPHAENA arms: 1% and 3%); no discontinuations of PH FDC SC have been recorded so far. Our findings also suggest that a history of drug or food allergies is a predictive factor for carboplatin-related hypersensitivity. -, A fatal anaphylactic reaction to paclitaxel is described, which was preceded by a possible delayed reaction to the initial infusion. Markman, M. (2007). Hypersensitivity reactions associated with platinum-containing antineoplastic agents for thoracic malignancies. Keywords: Oncol. Patients without ovarian cancer were excluded from retrospective analysis of details of hypersensitivity reactions recorded contemperaneously between April 2019 - January 2020 on excel and chemocare (CIS Oncology, Belfast, UK) by the treating practitioner. Prior to an infusion of a mAb, nurses should do the following (Olsen et al., 2019): . We analyzed the incidence, characteristics, risk factors, management, and outcomes of carboplatin-related hypersensitivity reactions among these patients. Vaccines (Basel). The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. A spotlight on alkaloid nanoformulations for the treatment of lung cancer. Have a look to the ESMO 2017 Programme online! J Investig Allergol Clin Immunol. By delivering the target, Symptoms and signs of hypersensitivity reactions amendable to desensitization. Blood. Characteristics of the 735 women receiving carboplatin-based chemotherapy. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordan on behalf of the ESMO Guidelines Committee These ESMO Clinical Practice Guidelines provide recommendations on the . Drug Interactions in the Treatment of Malignancy in HIV-Infected Patients. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. official website and that any information you provide is encrypted government site. The incidence of carboplatin-related hypersensitivity correlated with cycle number and dose, with the first episode occurring at a median of 12 cycles and 6,816 mg. Authorship includes a multidisciplinary group of experts from different institutions and countries in Europe and abroad. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. doi: 10.2152/jmi.57.163, PubMed Abstract | CrossRef Full Text | Google Scholar, Altwerger, G., Gressel, G. M., English, D. P., Nelson, W. K., Carusillo, N., Silasi, D. A., et al. Would you like email updates of new search results? Federal government websites often end in .gov or .mil. 4-step 4-h carboplatin desensitization protocol for patients with gynecological malignancies showing platinum hypersensitivity: a retrospective study. Author Information. Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the ESMO events app. doi: 10.1016/j.ygyno.2006.10.047, Shah, A. C., Minturn, J. E., Li, Y., Belasco, J. Expert Opin Drug Saf (2003) 2(6):597607.10.1517/14740338.2.6.597 2017 Nov 8;8:1472. doi: 10.3389/fimmu.2017.01472. Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel and carboplatin for patients with platinum-sensitive ovarian cancer in late relapse. J. (2005) reported that all carboplatin-associated hypersensitivity reactions occur in patients with prior carboplatin exposure, and Tamiya et al. Multivariate analysis was conducted using logistic regression to estimate the association between the potential risk factors and the occurrence of hypersensitivity. Carboplatin hypersensitivity: does introduction of skin test and desensitization reliably predict and avoid the problem? 2011 Aug;12(8):806-14. doi: 10.1016/S1470-2045(10)70208-4. Monitor. PMC Allergic and non-allergic ovarian cancer patients treated with carboplatin or carboplatin desensitization presented a similar life expectancy with a non significant advantage for the allergy desensitized patients. 2023 Feb 15;24(4):3886. doi: 10.3390/ijms24043886. Oncol. The most commonly exhibited symptom/sign was hypotension (10.7%), followed by anaphylaxis (8.0%) and desaturation (6.7%). Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Though the characteristics of carboplatin-related hypersensitivity reactions are widely reported, limited data are available regarding such reactions in different types of patients. Information for media including press accreditation. Int. 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Desensitization for hypersensitivity reactions to medications. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. doi: 10.1007/s00280-009-1159-6, Iwamoto, T., Hirai, H., Yamaguchi, N., Kobayashi, N., Sugimoto, H., and Tabata, T. (2014). See this image and copyright information in PMC. The cumulative incidence of carboplatin-related hypersensitivity was 2% after 8 cycles, 6% after 14 cycles, 8% after 19 cycles, and 10% after 33 cycles, with a plateau beyond this cycle number (Figure 1A). eCollection 2017. Accessibility Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions. The BRCA status of our patients was not available for further analysis in this retrospective study. Management of infusion reactions to systemic anticancer therapy: ESMO Therefore, the preferred regimen for platinum-sensitive recurrent ovarian cancer is carboplatin combined with paclitaxel, liposomal doxorubicin, or gemcitabine. Request PDF | On Jul 13, 2017, Susana Rosell Kernen published Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines | Find, read and cite all the . Drug allergy is a rising problem in the twenty-first century which affects all populations and races, children, and adults, and for which the recognition, diagnosis, management, and treatment is still not well standardized. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. and transmitted securely. Chan. Gynecol. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Bethesda, MD 20894, Web Policies Compared to those without hypersensitivity reactions, women who experienced hypersensitivity reactions had a significantly higher median number of cycles (12 vs. 6, P < 0.001, independent sample t-test) and dose (6,816 vs. 3,844 mg, P < 0.001, independent sample t-test, Table 3). Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. We found a higher incidence of carboplatin-related hypersensitivity among patients with advanced disease (stage IIIIV) with serous carcinoma and malignant ascites.